摘要: 超氧化物歧化酶（SOD）是一种重要的抗氧化酶，它能催化超氧化物自由基转化为氧气和过氧化氢，在降低氧化应激中起着至关重要的作用。本研究以从南极土壤中分离得到的高SOD活性极地酵母菌Cryptococcus albidosimilis为研究对象。该酵母表现出优异的抗寒、抗紫外线和抗氧化应激能力，有望成为稳定SOD的来源。我们对C. albidosimilis SOD进行了表征，结果表明其活性约为3000 U/mg，显著高于传统酵母。其显著特点包括增强的结构稳定性，在模拟胃液条件下仍能保持80%的活性，在45℃下可维持90%的活性长达30小时。此外，该酶独特的分子结构增强了其对环境压力的抵御能力。结合SOD分析，我们在Biowell实验室进行了一项独家实验，以评估我们专有的Pure-Glo美白成分的潜力。该成分包含白色隐球菌SOD、谷胱甘肽、冰川水提取物和白番茄提取物。该配方显示出显著抑制MITF（小眼畸形相关转录因子）基因信号传导的能力，该基因信号传导是黑色素生成的关键调控因子，抑制率达到67%。这一突破进一步证实了Pure-Glo作为基因层面靶向美白剂的有效性。

Abstract: Superoxide dismutase (SOD) is an essential antioxidant enzyme that catalyzes the conversion of superoxide radicals into oxygen and hydrogen peroxide, playing a crucial role in reducing oxidative stress. This study focuses on Cryptococcus albidosimilis, a polar yeast with high SOD activity, isolated from Antarctic soil. This yeast exhibits impressive resistance to cold, ultraviolet radiation, and oxidative stress, positioning it as a promising source of stable SOD. Our research characterizes C. albidosimilis SOD, revealing activity levels of about 3000 U/mg, significantly higher than those of conventional yeasts. Notable features include enhanced structural stability, retaining 80% activity under simulated gastric conditions and sustaining 90% activity at 45。C for up to 30 hours. Additionally, the unique molecular structure of this enzyme enhances its resilience against environmental stressors. In conjunction with the SOD analysis, we conducted an exclusive experiment at Biowell's laboratory to evaluate the potential of our proprietary Pure-Glo whitening composition, which incorporates Cryptococcus albidosimilis SOD along with glutathione, glacial water extract, and white tomato extract. This formulation demonstrated a significant ability to inhibit MITF (Microphthalmia-Associated Transcription Factor) gene signaling, a critical regulatory factor in melanin production, achieving a 67% inhibition rate. This breakthrough further confirms the effectiveness of Pure-Glo as a targeted skin whitening agent that operates at the genetic level.